Kinetics of Nucleo- and Spike Protein-Specific Immunoglobulin G and of Virus-Neutralizing Antibodies after SARS-CoV-2 Infection

In einer Vergleichsstudie von Strömer et al. 2020 wurde die Performance von acht verschiedenen Anti-SARS-CoV-2 Immunoassays mit 26 PCR positiven Proben, 27 Seren die neutralisierende Antikörper gegen SARS-CoV-2 enthalten sowie 100 Seren, die vor der Pandemie gesammelt wurden, analysiert.

Ergebnisse:

• “Both tests [Virion and Abbott] turned out to be the most sensitive and specific assays in the validation part of the study.“
• “While the N-based IgG assay [Abbott] revealed the existence of two groups of individuals, and one of them showed a rapid decrease of IgG indices within a few months, the IgG reactivity in the S protein-based assay [Virion] was found to be more stable.“
• “This is in-line with a previous preprint (Ripperger et al.) and could suggest that the latter test [Virion] is better suited for epidemiological studies, especially when it comes to questions of prevalence.“

^[1] SARS-CoV-2 RNA was previously detected in the PCR test. ^[2] SARS-CoV-2-neutralizing antibodies with a titer >1:10 were demonstrated in the plaque reduction neutralization test (PRNT). ^[3] 100 stored sera from 2018/2019

Anmerkung: Die höchsten Werte sind grün und die niedrigsten Werte in rot dargestellt.

Klicken Sie hier um zur Studie zu gelangen!